RYBELSUS® vs Other Diabetes Pills

Once-daily RYBELSUS® is a prescription medicine used along with diet and exercise to improve blood sugar in adults with type 2 diabetes.

RYBELSUS® vs a leading branded pill (JANUVIA®)

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RYBELSUS® lowered blood sugar better

At 6 months, adults with an average starting A1C of 8.3% lowered their A1C by an average of:

Average change in A1C comparison

Results are from a 6-month medical study of 1864 adults with type 2 diabetes that compared 7 mg RYBELSUS® and 14 mg RYBELSUS® with 100 mg JANUVIA® when both were added to 1 or 2 diabetes pills.

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While RYBELSUS® is not for weight loss, you may also lose some weight

At 6 months, in the same study looking at A1C, people who weighed an average of 200 pounds, on average, lost around:

  • 4.8 pounds while taking 7 mg of RYBELSUS®
  • 6.8 pounds while taking 14 mg of RYBELSUS®
  • 1.3 pounds while taking 100 mg of JANUVIA®
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People taking 14 mg of RYBELSUS® lost 5x more weight than people taking JANUVIA®.

Results are from a 6-month medical study of 1864 adults with type 2 diabetes that compared 7 mg RYBELSUS® and 14 mg RYBELSUS® with 100 mg JANUVIA® when both were added to 1 or 2 diabetes pills.

While many people in medical studies lost weight, some did gain weight.

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Need to get your A1C DOWN?

RYBELSUS® is a prescription medicine for type 2 diabetes that is used along with diet and exercise to improve blood sugar and A1C. Learn ways to make diet and exercise a part of your daily routine.

LEARN MORE

Need to get your A1C DOWN?

RYBELSUS® is a prescription medicine for type 2 diabetes that is used along with diet and exercise to improve blood sugar and A1C. Learn ways to make diet and exercise a part of your daily routine.

LEARN MORE

Need to get your A1C DOWN?

RYBELSUS® is a prescription medicine for type 2 diabetes that is used along with diet and exercise to improve blood sugar and A1C. Learn ways to make diet and exercise a part of your daily routine.

LEARN MORE

RYBELSUS® vs JARDIANCE®

A1C down arrow

RYBELSUS® lowered blood sugar better

At 6 months, adults with an average starting A1C of 8.1% lowered their A1C by an average of:

Average change in A1C comparison

Results are from a 6-month medical study of 822 adults with type 2 diabetes that compared 14 mg RYBELSUS® with 25 mg JARDIANCE® when both were added to another diabetes pill.

Scale

While RYBELSUS® is not for weight loss, you may also lose some weight

At 6 months, in a medical study, people who weighed an average of 202 pounds, on average, lost around:

  • 8.4 pounds while taking 14 mg of RYBELSUS®
  • 8.1 pounds while taking 25 mg of JARDIANCE®
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The average weight loss was about the same in people taking 14 mg of RYBELSUS® and in people taking 25 mg of JARDIANCE®.

Light bulb

The average weight loss was about the same in people taking 14 mg of RYBELSUS® and in people taking 25 mg of JARDIANCE®.

Results are from a 6-month medical study of 822 adults with type 2 diabetes that compared 14 mg RYBELSUS® with 25 mg JARDIANCE® when both were added to another diabetes pill.

While many people in medical studies lost weight, some did gain weight.

Carolyn smiling Carolyn smiling

My A1C wasn't at goal. Now I'm DOWN with RYBELSUS®.

Carolyn's A1C is DOWN with RYBELSUS®.

SEE MY STORY
RYBELSUS® patient shown is a paid spokesperson for Novo Nordisk.
NEXT: How RYBELSUS® Works
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Get your A1C DOWN with RYBELSUS®

Once-daily RYBELSUS® is proven to significantly lower A1C.

LEARN MORE
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Pay as little as $10 for up to a 3-month RYBELSUS® 
prescriptiona

Check your insurance coverage and learn about ways to save.

START SAVING

aTo receive offer, 7 mg or 14 mg dose prescription must be for a 1-, 2-, or 3-month supply. For 3 mg dose, pay as little as $10 each month. Eligible, commercially insured patients with product coverage only. Maximum savings of $300 per 1‑month supply, $600 per 2‑month supply, or $900 per 3‑month supply. Eligibility and other restrictions apply.

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Support to help you start and stay on RYBELSUS®

RYBELSUS® Connect offers support when and where you need it. Textb READY to 21848 to get started.

MORE INFO

aTo receive offer, 7 mg or 14 mg dose prescription must be for a 1-, 2-, or 3-month supply. For 3 mg dose, pay as little as $10 each month. Eligible, commercially insured patients with product coverage only. Maximum savings of $300 per 1‑month supply, $600 per 2‑month supply, or $900 per 3‑month supply. Eligibility and other restrictions apply.

bMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Use.

What is RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.

  • RYBELSUS® is not for use in people with type 1 diabetes
  • It is not known if RYBELSUS® is safe and effective for use in children

Important Safety Information

What is the most important information I should know about RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

  • Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, RYBELSUS® and medicines that work like RYBELSUS® caused thyroid tumors, including thyroid cancer. It is not known if RYBELSUS® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people

Do not use RYBELSUS® if:

  • you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • you have had a serious allergic reaction to semaglutide or any of the ingredients in RYBELSUS®. See symptoms of serious allergic reaction in "What are the possible side effects of RYBELSUS®?"

Before using RYBELSUS®, tell your healthcare provider if you have any other medical conditions, including if you:

  • have or have had problems with your pancreas or kidneys
  • have a history of vision problems related to your diabetes
  • are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)
  • are pregnant or plan to become pregnant. It is not known if RYBELSUS® will harm your unborn baby. You should stop using RYBELSUS® 2 months before you plan to become pregnant
  • are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with RYBELSUS®

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. RYBELSUS® may affect the way some medicines work and some medicines may affect the way RYBELSUS® works.

How should I take RYBELSUS®?

  • Take RYBELSUS® exactly as your healthcare provider tells you to
  • Do not take more than 1 tablet each day
  • Take RYBELSUS® by mouth on an empty stomach in the morning with a sip of plain water (no more than 4 ounces). Do not take  RYBELSUS® with any other liquids besides water
  • Do not split, crush, or chew. Swallow RYBELSUS® whole
  • After 30 minutes, you can eat, drink, or take other oral medicines
  • If you miss a dose of RYBELSUS®, skip the missed dose and go back to your regular schedule

What are the possible side effects of RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

  • inflammation of your pancreas (pancreatitis). Stop using RYBELSUS® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
  • changes in vision. Tell your healthcare provider if you have changes in vision during treatment with RYBELSUS®
  • low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use RYBELSUS® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery
  • kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration
  • severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use RYBELSUS®. Tell your healthcare provider if you have stomach problems that are severe or will not go away
  • serious allergic reactions. Stop using RYBELSUS® and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
  • gallbladder problems. Gallbladder problems have happened in some people who take RYBELSUS®. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include: pain in your upper stomach (abdomen), yellowing of skin or eyes (jaundice), fever, and clay-colored stools
  • food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). RYBELSUS® may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking RYBELSUS® before you are scheduled to have surgery or other procedures

The most common side effects of RYBELSUS® may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and diarrhea are most common when you first start RYBELSUS®.

Please see Prescribing Information and Medication Guide for RYBELSUS®.

RYBELSUS® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.